Endolysosome Localization of ER&#945; Is Involved in the Protective Effect of 17&#945;-Estradiol against HIV-1 gp120-Induced Neuronal Injury.

Datta, Gaurav; Miller, Nicole M; Du, Wenjuan; Geiger, Jonathan D; Chang, Sulie; Chen, Xuesong

Endolysosome Localization of ERα Is Involved in the Protective Effect of 17α-Estradiol against HIV-1 gp120-Induced Neuronal Injury.

Datta, Gaurav; Miller, Nicole M; Du, Wenjuan; Geiger, Jonathan D; Chang, Sulie; Chen, Xuesong.

Afiliação

Datta G; Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202-9037.
Miller NM; Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202-9037.
Du W; Institute of Neuroimmune Pharmacology and Department of Biological Sciences, Seton Hall University, South Orange, New Jersey 07079.
Geiger JD; Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202-9037.
Chang S; Institute of Neuroimmune Pharmacology and Department of Biological Sciences, Seton Hall University, South Orange, New Jersey 07079.
Chen X; Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202-9037 xuesong.chen@und.edu.

J Neurosci ; 41(50): 10365-10381, 2021 12 15.

Article em En | MEDLINE | ID: mdl-34764157

Assuntos

Complexo AIDS Demência; Estradiol/farmacologia; Receptor alfa de Estrogênio/metabolismo; Proteína gp120 do Envelope de HIV/toxicidade; Lisossomos/metabolismo; Neurônios/metabolismo; Animais; Células Cultivadas; Feminino; Hipocampo/efeitos dos fármacos; Hipocampo/metabolismo; Masculino; Neurônios/efeitos dos fármacos; Ratos; Ratos Endogâmicos F344; Ratos Transgênicos

Palavras-chave

17a-estradiol; ERa; HIV-1 gp120; HIV-associated neurocognitive disorders; dendritic spine; lysosome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína gp120 do Envelope de HIV / Complexo AIDS Demência / Receptor alfa de Estrogênio / Estradiol / Lisossomos / Neurônios Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: J Neurosci Ano de publicação: 2021 Tipo de documento: Article

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