Pure red cell aplasia accompanied by COVID-19 successfully treated using cyclosporine.
J Infect Chemother
; 28(2): 304-307, 2022 Feb.
Article
em En
| MEDLINE
| ID: mdl-34772624
ABSTRACT
A 67-year-old Japanese man was admitted to our hospital with severe coronavirus disease 2019 (COVID-19) in March 2020. Mechanical ventilation was initiated 8 days after admission, due to severe respiratory failure. Multiple severe complications such as liver dysfunction, arrhythmia, brain infarction, and venous thromboembolism were also observed. We initially diagnosed Coombs test-positive warm autoimmune hemolytic anemia. Corticosteroids proved ineffective and anemia worsened with severe erythroid hypoplasia (0.5% erythroblasts in bone marrow), so we diagnosed pure red cell aplasia (PRCA). We also identified massive infiltration of cytotoxic T-lymphocytes expressing CD8, granzyme B, and perforin in bone marrow. Systemic cyclosporine was started, with full resolution of anemia and no need for blood transfusions after 4 weeks. We believe that this represents the first report of COVID-19-associated PRCA successfully treated using cyclosporine.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aplasia Pura de Série Vermelha
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COVID-19
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Anemia Hemolítica Autoimune
Tipo de estudo:
Prognostic_studies
Limite:
Aged
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Humans
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Male
Idioma:
En
Revista:
J Infect Chemother
Assunto da revista:
MICROBIOLOGIA
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TERAPIA POR MEDICAMENTOS
Ano de publicação:
2022
Tipo de documento:
Article