The gut microbiome of extremely preterm infants randomized to the early progression of enteral feeding.
Pediatr Res
; 92(3): 799-804, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-34775476
ABSTRACT
BACKGROUND:
Early progression of feeding could influence the development of the gut microbiome.METHODS:
We collected fecal samples from extremely preterm infants randomized to receive either early (feeding day 2) or delayed (feeding day 5) feeding progression. After study completion, we compared samples obtained at three different time points (week 1, week 2, and week 3) to determine longitudinal differences in specific taxa between the study groups using unadjusted and adjusted negative binomial and zero-inflated mixed models. Analyses were adjusted for a mode of delivery, breastmilk intake, and exposure to antibiotics.RESULTS:
We analyzed 137 fecal samples from 51 infants. In unadjusted and adjusted analyses, we did not observe an early transition to higher microbial diversity within samples (i.e., alpha diversity) or significant differences in microbial diversity between samples (i.e., beta diversity) in the early feeding group. Our longitudinal, single-taxon analysis found consistent differences in the genera Lactococcus, Veillonella, and Bilophila between groups.CONCLUSIONS:
Differences in single-taxon analyses independent of the mode of delivery, exposure to antibiotics, and breastmilk feeding suggest potential benefits of early progression of enteral feeding volumes. However, this dietary intervention does not appear to increase the diversity of the gut microbiome in the first 28 days after birth. TRIAL REGISTRATION ClinicalTrials.gov identifier NCT02915549. IMPACT Early progression of enteral feeding volumes with human milk reduces the duration of parenteral nutrition and the need for central venous access among extremely preterm infants. Early progression of enteral feeding leads to single-taxon differences in longitudinal analyses of the gut microbiome, but it does not appear to increase the diversity of the gut microbiome in the first 28 days after birth. Randomization in enteral feeding trials creates appealing opportunities to evaluate the effects of human milk diets on the gut microbiome.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nutrição Enteral
/
Microbioma Gastrointestinal
Tipo de estudo:
Clinical_trials
Limite:
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
Pediatr Res
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos