Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.

Hu, Dennis X; Patel, Snahel; Chen, Huifen; Wang, Shumei; Staben, Steven T; Dimitrova, Yoana N; Wallweber, Heidi Ackerly; Lee, Joanna Y; Chan, Grace Ka Yan; Sneeringer, Christopher J; Prangley, Madeleine S; Moffat, John G; Wu, Kai C; Schutt, Leah K; Salphati, Laurent; Pang, Jodie; McNamara, Erin; Huang, Haochu; Chen, Yong; Wang, Yunli; Zhao, Wensheng; Lim, Junghyun; Murthy, Aditya; Siu, Michael

Hu, Dennis X; Patel, Snahel; Chen, Huifen; Wang, Shumei; Staben, Steven T; Dimitrova, Yoana N; Wallweber, Heidi Ackerly; Lee, Joanna Y; Chan, Grace Ka Yan; Sneeringer, Christopher J; Prangley, Madeleine S; Moffat, John G; Wu, Kai C; Schutt, Leah K; Salphati, Laurent; Pang, Jodie; McNamara, Erin; Huang, Haochu; Chen, Yong; Wang, Yunli; Zhao, Wensheng; Lim, Junghyun; Murthy, Aditya; Siu, Michael.

Afiliação

Chen Y; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, China.
Wang Y; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, China.
Zhao W; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, China.

J Med Chem ; 65(17): 11500-11512, 2022 09 08.

Article em En | MEDLINE | ID: mdl-34779204

Assuntos

Antineoplásicos; Classe III de Fosfatidilinositol 3-Quinases; Antineoplásicos/metabolismo; Antineoplásicos/farmacologia; Autofagia; Endossomos; Fosfatidilinositol 3-Quinase/metabolismo; Fosforilação

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Classe III de Fosfatidilinositol 3-Quinases / Antineoplásicos Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article

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