Roles of the tissue-type plasminogen activator in immune response.
Cell Immunol
; 371: 104451, 2022 01.
Article
em En
| MEDLINE
| ID: mdl-34781155
ABSTRACT
The COVID-19 pandemic has once again brought to the forefront the existence of a tight link between the coagulation/fibrinolytic system and the immunologic processes. Tissue-type plasminogen activator (tPA) is a serine protease with a key role in fibrinolysis by converting plasminogen into plasmin that can finally degrade fibrin clots. tPA is released in the blood by endothelial cells and hepatocytes but is also produced by various types of immune cells including T cells and monocytes. Beyond its role on hemostasis, tPA is also a potent modulator of inflammation and is involved in the regulation of several inflammatory diseases. Here, after a brief description of tPA structure, we review its new functions in adaptive immunity focusing on T cells and antigen presenting cells. We intend to synthesize the recent knowledge on proteolysis- and receptor-mediated effects of tPA on immune response in physiological and pathological context.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Coagulação Sanguínea
/
Ativador de Plasminogênio Tecidual
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Fibrinólise
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SARS-CoV-2
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COVID-19
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Imunidade
Limite:
Humans
Idioma:
En
Revista:
Cell Immunol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
França