Rational Design of Self-Assembled Mitochondria-Targeting Lytic Peptide Conjugates with Enhanced Tumor Selectivity.

Liu, Sijin; Wang, Biao; Sheng, Yina; Dong, Suwei; Liu, Guoquan

Liu, Sijin; Wang, Biao; Sheng, Yina; Dong, Suwei; Liu, Guoquan.

Afiliação

Liu S; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Wang B; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Sheng Y; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Dong S; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
Liu G; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.

Chemistry ; 28(3): e202103517, 2022 Jan 13.

Article em En | MEDLINE | ID: mdl-34791722

Assuntos

Antineoplásicos; Nanopartículas; Neoplasias; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Humanos; Mitocôndrias; Neoplasias/tratamento farmacológico; Peptídeos/uso terapêutico

Palavras-chave

lysosomal escape; membrane lytic peptides; mitochondria-targeting; self-assembly; tumor selectivity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas / Neoplasias / Antineoplásicos Limite: Humans Idioma: En Revista: Chemistry Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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