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Influence of inter-electrode distance on subthalamic nucleus local field potential recordings in Parkinson's disease.
Averna, Alberto; Marceglia, Sara; Arlotti, Mattia; Locatelli, Marco; Rampini, Paolo; Priori, Alberto; Bocci, Tommaso.
Afiliação
  • Averna A; Aldo Ravelli" Research Center for Neurotechnology and Experimental Neurotherapeutics, Department of Health Sciences, University of Milan, 20142 Milan, Italy.
  • Marceglia S; Department of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy.
  • Arlotti M; Newronika S.r.l., 20093 Cologno Monzese, Italy.
  • Locatelli M; Aldo Ravelli" Research Center for Neurotechnology and Experimental Neurotherapeutics, Department of Health Sciences, University of Milan, 20142 Milan, Italy; Department of Neurosurgery, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transpla
  • Rampini P; Department of Neurosurgery, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
  • Priori A; Aldo Ravelli" Research Center for Neurotechnology and Experimental Neurotherapeutics, Department of Health Sciences, University of Milan, 20142 Milan, Italy; Clinical Neurology Unit I, San Paolo University Hospital, ASST Santi Paolo e Carlo and Department of Health Sciences, 20142 Milan, Italy.
  • Bocci T; Aldo Ravelli" Research Center for Neurotechnology and Experimental Neurotherapeutics, Department of Health Sciences, University of Milan, 20142 Milan, Italy; Clinical Neurology Unit I, San Paolo University Hospital, ASST Santi Paolo e Carlo and Department of Health Sciences, 20142 Milan, Italy.. Ele
Clin Neurophysiol ; 133: 29-38, 2022 01.
Article em En | MEDLINE | ID: mdl-34794045
OBJECTIVES: To evaluate spectra and their correlations with clinical symptoms of local field potentials (LFP) acquired from wide- and close-spaced contacts (i.e. between contacts 0-3 or LFP03, and contacts 1-2 or LFP12 respectively) on the same DBS electrode within the subthalamus (STN) in Parkinson's disease (PD), before and after levodopa administration. METHODS: LFP12 and LFP03 were recorded from 20 PD patients. We evaluated oscillatory power, local and switched phase-amplitude coupling (l- and Sw-PAC) and correlation with motor symptoms (UPDRSIII). RESULTS: Before levodopa, both LFP03 and LFP12 power in the α band inversely correlated with UPDRSIII. Differences between contacts were found in the low-frequency bands power. After levodopa, differences in UPDRSIII were associated to changes in LFP03 low-ß and LFP12 HFO (high frequency oscillations, 250-350 Hz) power, while a modulation of the low-ß power and an increased ß-LFO (low frequency oscillations, 15-45 Hz) PAC was found only for LFP12. CONCLUSION: This study reveals differences in spectral pattern between LFP12 and LFP03 before and after levodopa administration, as well as different correlations with PD motor symptoms. SIGNIFICANCE: Differences between LFP12 and LFP03 may offer an opportunity for optimizing adaptive deep brain stimulation (aDBS) protocols for PD. LFP12 can be used to detect ß-HFO coupling and ß power (i.e. bradykinesia), while LFP03 are optimal for low frequency oscillations (dyskinesias).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Núcleo Subtalâmico / Potenciais da Membrana Tipo de estudo: Guideline Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Neurophysiol Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Núcleo Subtalâmico / Potenciais da Membrana Tipo de estudo: Guideline Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Neurophysiol Assunto da revista: NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália