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Evaluation of a Three-Dimensional Primary Human Hepatocyte Spheroid Model: Adoption and Industrialization for the Enhanced Detection of Drug-Induced Liver Injury.
Schofield, Christopher A; Walker, Tracy M; Taylor, Maxine A; Patel, Metul; Vlachou, Denise F; Macina, Justyna M; Vidgeon-Hart, Martin P; Williams, Ann; McGill, Paul J; Newman, Carla F; Sakatis, Melanie Z.
Afiliação
  • Schofield CA; Functional Genomics, Medicinal Science and Technology, GlaxoSmithKline Research and Development, Stevenage, Herts SG1 2NY, United Kingdom.
  • Walker TM; Oncology Cell Therapy, Oncology Therapy Area, GlaxoSmithKline Research and Development, Stevenage, Herts SG1 2NY, United Kingdom.
  • Taylor MA; Drug Metabolism and Pharmacokinetics, In Vitro/In Vivo Translation, GlaxoSmithKline Research and Development, Ware, Herts SG12 0DP, United Kingdom.
  • Patel M; Screening, Profiling and Mechanistic Biology, Medicinal Science and Technology, GlaxoSmithKline Research and Development, Stevenage, Herts SG1 2NY, United Kingdom.
  • Vlachou DF; Molecular Design U.K., Medicinal Science and Technology, GlaxoSmithKline Research and Development, Stevenage, Herts SG1 2NY, United Kingdom.
  • Macina JM; Screening, Profiling and Mechanistic Biology, Medicinal Science and Technology, GlaxoSmithKline Research and Development, Stevenage, Herts SG1 2NY, United Kingdom.
  • Vidgeon-Hart MP; Non Clinical Safety, In Vitro/In Vivo Translation, GlaxoSmithKline Research and Development, Ware, Herts SG12 0DP, United Kingdom.
  • Williams A; Pathology U.K., In Vitro/In Vivo Translation, GlaxoSmithKline Research and Development, Ware, Herts SG12 0DP, United Kingdom.
  • McGill PJ; Bioimaging U.K., In Vitro/In Vivo Translation, GlaxoSmithKline Research and Development, Ware, Herts SG12 0DP, United Kingdom.
  • Newman CF; Bioimaging U.K., In Vitro/In Vivo Translation, GlaxoSmithKline Research and Development, Stevenage, Herts SG1 2NY, United Kingdom.
  • Sakatis MZ; Non Clinical Safety, In Vitro/In Vivo Translation, GlaxoSmithKline Research and Development, Ware, Herts SG12 0DP, United Kingdom.
Chem Res Toxicol ; 34(12): 2485-2499, 2021 12 20.
Article em En | MEDLINE | ID: mdl-34797640
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Esferoides Celulares / Hepatócitos / Doença Hepática Induzida por Substâncias e Drogas / Modelos Biológicos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Chem Res Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Esferoides Celulares / Hepatócitos / Doença Hepática Induzida por Substâncias e Drogas / Modelos Biológicos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Chem Res Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido