Investigation on the antitumor effects of paeonol against renal cell carcinoma based on network pharmacology and experimental validation.

Chen, Yajing; Jia, Yuchen; Li, Yuxin; Zheng, Yuanqiang; Chen, Guojiang; Shi, Yanchun

Chen, Yajing; Jia, Yuchen; Li, Yuxin; Zheng, Yuanqiang; Chen, Guojiang; Shi, Yanchun.

Afiliação

Chen Y; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China; Inner Mongolia Key Laboratory of Molecular Biology, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010058, China.
Jia Y; Inner Mongolia Key Laboratory of Molecular Biology, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010058, China.
Li Y; Inner Mongolia Key Laboratory of Molecular Biology, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010058, China.
Zheng Y; Inner Mongolia Key Laboratory of Molecular Biology, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010058, China. Electronic address: zhengyq688@163.com.
Chen G; State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Beijing, 100850, China. Electronic address: jyk62033@163.com.
Shi Y; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China; Inner Mongolia Key Laboratory of Molecular Biology, School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010058, China. Electronic address: shiyc@immu.edu.c

J Ethnopharmacol ; 285: 114857, 2022 Mar 01.

Article em En | MEDLINE | ID: mdl-34813895

Assuntos

Acetofenonas/farmacologia; Antineoplásicos Fitogênicos/farmacologia; Carcinoma de Células Renais/tratamento farmacológico; Fitoterapia; Acetofenonas/administração & dosagem; Acetofenonas/química; Antineoplásicos Fitogênicos/química; Apoptose; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Relação Dose-Resposta a Droga; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Estrutura Molecular; Farmacologia em Rede; Mapas de Interação de Proteínas; Reprodutibilidade dos Testes

Palavras-chave

Apoptosis; Bax/Bcl-2; Network pharmacology; Paeonol; Renal cell carcinoma; VEGFA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acetofenonas / Carcinoma de Células Renais / Fitoterapia / Antineoplásicos Fitogênicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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