Frailty and pain, human studies and animal models.
Ageing Res Rev
; 73: 101515, 2022 01.
Article
em En
| MEDLINE
| ID: mdl-34813977
ABSTRACT
The hypothesis that pain can predispose to frailty development has been recently investigated in several clinical studies suggesting that frailty and pain may share some mechanisms. Both pain and frailty represent important clinical and social problems and both lack a successful treatment. This circumstance is mainly due to the absence of in-depth knowledge of their pathological mechanisms. Evidence of shared pathways between frailty and pain are preliminary. Indeed, many clinical studies are observational and the impact of pain treatment, and relative pain-relief, on frailty onset and progression has never been investigated. Furthermore, preclinical research on this topic has yet to be performed. Specific researches on the pain-frailty relation are needed. In this narrative review, we will attempt to point out the most relevant findings present in both clinical and preclinical literature on the topic, with particular attention to genetics, epigenetics and inflammation, in order to underline the existing gaps and the potential future interventional strategies. The use of pain and frailty animal models discussed in this review might contribute to research in this area.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fragilidade
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Aged
/
Animals
/
Humans
Idioma:
En
Revista:
Ageing Res Rev
Assunto da revista:
GERIATRIA
Ano de publicação:
2022
Tipo de documento:
Article