Cytotoxic Indole-Diterpenoids from the Marine-Derived Fungus Penicillium sp. KFD28.
Mar Drugs
; 19(11)2021 Oct 28.
Article
em En
| MEDLINE
| ID: mdl-34822484
ABSTRACT
Four new indole-diterpenoids, named penerpenes K-N (1-4), along with twelve known ones (5-16), were isolated from the fermentation broth produced by adding L-tryptophan to the culture medium of the marine-derived fungus Penicillium sp. KFD28. The structures of the new compounds were elucidated extensively by 1D and 2D NMR, HRESIMS data spectroscopic analyses and ECD calculations. Compound 4 represents the second example of paxilline-type indole diterpene bearing a 1,3-dioxepane ring. Three compounds (4, 9, and 15) were cytotoxic to cancer cell lines, of which compound 9 was the most active and showed cytotoxic activity against the human liver cancer cell line BeL-7402 with an IC50 value of 5.3 µM. Moreover, six compounds (5, 7, 10, 12, 14, and 15) showed antibacterial activities against Staphylococcus aureus ATCC 6538 and Bacillus subtilis ATCC 6633.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Penicillium
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Diterpenos
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Indóis
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Antibacterianos
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Antineoplásicos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Mar Drugs
Assunto da revista:
BIOLOGIA
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FARMACOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China