Pharmacogenomic analysis of a genetically distinct Indigenous population.
Pharmacogenomics J
; 22(2): 100-108, 2022 03.
Article
em En
| MEDLINE
| ID: mdl-34824386
ABSTRACT
Indigenous Australians face a disproportionately severe burden of chronic disease relative to other Australians, with elevated rates of morbidity and mortality. While genomics technologies are slowly gaining momentum in personalised treatments for many, a lack of pharmacogenomic research in Indigenous peoples could delay adoption. Appropriately implementing pharmacogenomics in clinical care necessitates an understanding of the frequencies of pharmacologically relevant genetic variants within Indigenous populations. We analysed whole-genome sequence data from 187 individuals from the Tiwi Islands and characterised the pharmacogenomic landscape of this population. Specifically, we compared variant profiles and allelic distributions of previously described pharmacologically significant genes and variants with other population groups. We identified 22 translationally relevant pharmacogenomic variants and 18 clinically actionable guidelines with implications for drug dosing and treatment of conditions including heart disease, diabetes and cancer. We specifically observed increased poor and intermediate metabolizer phenotypes in the CYP2C9 (PM19%, IM44%) and CYP2C19 (PM18%, IM44%) genes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Testes Farmacogenômicos
/
Povos Indígenas
Tipo de estudo:
Guideline
Limite:
Humans
País/Região como assunto:
Oceania
Idioma:
En
Revista:
Pharmacogenomics J
Assunto da revista:
BIOLOGIA MOLECULAR
/
FARMACOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Austrália