RANK-C Expression Sensitizes ER-Negative, EGFR-Positive Breast Cancer Cells to EGFR-Tyrosine Kinase Inhibitors (TKIs).

Sirinian, Chaido; Papanastasiou, Anastasios D; Degn, Soren E; Frantzi, Theodora; Aronis, Christos; Chaniotis, Dimitrios; Makatsoris, Thomas; Koutras, Angelos; Kalofonos, Haralabos P

Sirinian, Chaido; Papanastasiou, Anastasios D; Degn, Soren E; Frantzi, Theodora; Aronis, Christos; Chaniotis, Dimitrios; Makatsoris, Thomas; Koutras, Angelos; Kalofonos, Haralabos P.

Afiliação

Sirinian C; Molecular Oncology Laboratory, Division of Oncology, Department of Medicine, University of Patras, 26504 Patras, Greece.
Papanastasiou AD; Department of Biomedical Sciences, University of West Attica, 12243 Athens, Greece.
Degn SE; Department of Biomedicine, Aarhus University, DK-8000 Aarhus C, Denmark.
Frantzi T; Molecular Oncology Laboratory, Division of Oncology, Department of Medicine, University of Patras, 26504 Patras, Greece.
Aronis C; Molecular Oncology Laboratory, Division of Oncology, Department of Medicine, University of Patras, 26504 Patras, Greece.
Chaniotis D; Department of Biomedical Sciences, University of West Attica, 12243 Athens, Greece.
Makatsoris T; Molecular Oncology Laboratory, Division of Oncology, Department of Medicine, University of Patras, 26504 Patras, Greece.
Koutras A; Molecular Oncology Laboratory, Division of Oncology, Department of Medicine, University of Patras, 26504 Patras, Greece.
Kalofonos HP; Molecular Oncology Laboratory, Division of Oncology, Department of Medicine, University of Patras, 26504 Patras, Greece.

Genes (Basel) ; 12(11)2021 10 23.

Article em En | MEDLINE | ID: mdl-34828291

Assuntos

Processamento Alternativo; Neoplasias da Mama/genética; Inibidores de Proteínas Quinases/farmacologia; Receptor Ativador de Fator Nuclear kappa-B/genética; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/metabolismo; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Receptores ErbB/metabolismo; Cloridrato de Erlotinib/farmacologia; Feminino; Gefitinibe/farmacologia; Humanos; Receptores de Estrogênio/metabolismo

Palavras-chave

EGFR; ER-negative; RANK-c; TKIs; breast cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Processamento Alternativo / Inibidores de Proteínas Quinases / Receptor Ativador de Fator Nuclear kappa-B Limite: Female / Humans Idioma: En Revista: Genes (Basel) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Grécia

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