Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity.
Int J Mol Sci
; 22(22)2021 Nov 09.
Article
em En
| MEDLINE
| ID: mdl-34830021
ABSTRACT
Original results are presented in the field of research that addresses the extension of the reaction of residue of acyl-thiosemicarbazide fixation on the structure of 5-nitrobenzimidazole by a sulphonic group. The aim of the study is the increase of new thiosemicarbazide derivatives' applicative potential in the field of biochemistry, with a wide range of medical applications. The newly obtained compounds were characterized by using elemental analysis and spectral analysis (FT-IR and 1H NMR). A study regarding the optimization of the chemical reactions was made. The performed in vitro biological tests confirmed the tuberculostatic activity of three newly obtained compounds against Mycobacterium tuberculosis.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Semicarbazidas
/
Tuberculose
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Mycobacterium tuberculosis
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Antituberculosos
Limite:
Humans
Idioma:
En
Revista:
Int J Mol Sci
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Romênia