Fermentation supernatant of Staphylococcus aureus drives catabolism in chondrocytes via NF-&#954;B signaling mediated increase of cholesterol metabolism.

Wang, Qian; Huang, Jiefeng; Li, Shuaijun; Zhang, Yun; Sun, Ruizhu; Ren, Jiaxin; Shi, Si; Cui, Lei

Fermentation supernatant of Staphylococcus aureus drives catabolism in chondrocytes via NF-κB signaling mediated increase of cholesterol metabolism.

Wang, Qian; Huang, Jiefeng; Li, Shuaijun; Zhang, Yun; Sun, Ruizhu; Ren, Jiaxin; Shi, Si; Cui, Lei.

Afiliação

Wang Q; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education of the People's Republic of China & Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, China; Department of Stem Cells and Regenerative Medicine, School of Medic
Huang J; Department of Stem Cells and Regenerative Medicine, School of Medicine, Tongji University, Shanghai, China.
Li S; Department of Stem Cells and Regenerative Medicine, School of Medicine, Tongji University, Shanghai, China.
Zhang Y; Institute for Regenerative Medicine & Department of Joint Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Sun R; Department of Stem Cells and Regenerative Medicine, School of Medicine, Tongji University, Shanghai, China.
Ren J; Department of Stem Cells and Regenerative Medicine, School of Medicine, Tongji University, Shanghai, China.
Shi S; Department of Stem Cells and Regenerative Medicine, School of Medicine, Tongji University, Shanghai, China.
Cui L; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education of the People's Republic of China & Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, China; Department of Stem Cells and Regenerative Medicine, School of Medic

Exp Cell Res ; 410(1): 112952, 2022 01 01.

Article em En | MEDLINE | ID: mdl-34848206

Assuntos

Artrite Infecciosa/genética; Cartilagem/crescimento & desenvolvimento; Osteoartrite/genética; Staphylococcus aureus/patogenicidade; Proteína ADAMTS5/genética; Artrite Infecciosa/microbiologia; Artrite Infecciosa/patologia; Cartilagem/metabolismo; Cartilagem/microbiologia; Cartilagem/patologia; Células Cultivadas; Colesterol/genética; Condrócitos/metabolismo; Condrócitos/microbiologia; Condrócitos/patologia; Família 7 do Citocromo P450/genética; Regulação da Expressão Gênica/genética; Humanos; Metaloproteinase 13 da Matriz/genética; Metabolismo/genética; NF-kappa B/genética; Óxido Nítrico Sintase Tipo II/genética; Membro 1 do Grupo F da Subfamília 1 de Receptores Nucleares/genética; Osteoartrite/microbiologia; Osteoartrite/patologia; Receptores Depuradores Classe E/genética; Transdução de Sinais/genética; Esteroide Hidroxilases/genética; Ácido Tauroquenodesoxicólico/genética; Fator de Transcrição RelA/genética

Palavras-chave

Cholesterol metabolism; Chondrocytes; Nuclear factor-kappa B; Septic arthritis; Staphylococcus aureus; TUDCA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoartrite / Staphylococcus aureus / Artrite Infecciosa / Cartilagem Limite: Humans Idioma: En Revista: Exp Cell Res Ano de publicação: 2022 Tipo de documento: Article

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