Isoforms of autophagy-related proteins: role in glioma progression and therapy resistance.
Mol Cell Biochem
; 477(2): 593-604, 2022 Feb.
Article
em En
| MEDLINE
| ID: mdl-34854022
ABSTRACT
Autophagy is the process of recycling and utilization of degraded organelles and macromolecules in the cell compartments formed during the fusion of autophagosomes with lysosomes. During autophagy induction the healthy and tumor cells adapt themselves to harsh conditions such as cellular stress or insufficient supply of nutrients in the cell environment to maintain their homeostasis. Autophagy is currently seen as a form of programmed cell death along with apoptosis and necroptosis. In recent years multiple studies have considered the autophagy as a potential mechanism of anticancer therapy in malignant glioma. Although, subsequent steps in autophagy development are known and well-described, on molecular level the mechanism of autophagosome initiation and maturation using autophagy-related proteins is under investigation. This article reviews current state about the mechanism of autophagy, its molecular pathways and the most recent studies on roles of autophagy-related proteins and their isoforms in glioma progression and its treatment.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Apoptose
/
Proteínas Relacionadas à Autofagia
/
Glioma
/
Proteínas de Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Mol Cell Biochem
Ano de publicação:
2022
Tipo de documento:
Article