Your browser doesn't support javascript.
loading
Modulation of the blood-tumor barrier to enhance drug delivery and efficacy for brain metastases.
Blethen, Kathryn E; Arsiwala, Tasneem A; Fladeland, Ross A; Sprowls, Samuel A; Panchal, Dhruvi M; Adkins, Chris E; Kielkowski, Brooke N; Earp, Leland E; Glass, Morgan J; Pritt, Trenton A; Cabuyao, Yssabela M; Aulakh, Sonikpreet; Lockman, Paul R.
Afiliação
  • Blethen KE; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA.
  • Arsiwala TA; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA.
  • Fladeland RA; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA.
  • Sprowls SA; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA.
  • Panchal DM; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA.
  • Adkins CE; Department of Chemical and Biomedical Engineering, Benjamin M. Statler College of Engineering and Mineral Resources, West Virginia University, Morgantown, West Virginia, USA.
  • Kielkowski BN; Department of Pharmaceutical Sciences, School of Pharmacy, South University, Savannah, Georgia, USA.
  • Earp LE; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA.
  • Glass MJ; Department of Cancer Cell Biology, School of Medicine, West Virginia University, Morgantown, West Virginia, USA.
  • Pritt TA; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA.
  • Cabuyao YM; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA.
  • Aulakh S; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia, USA.
  • Lockman PR; Department of Cancer Cell Biology, School of Medicine, West Virginia University, Morgantown, West Virginia, USA.
Neurooncol Adv ; 3(Suppl 5): v133-v143, 2021 Nov.
Article em En | MEDLINE | ID: mdl-34859240
The blood-brain barrier is the selectively permeable vasculature of the brain vital for maintaining homeostasis and neurological function. Low permeability is beneficial in the presence of toxins and pathogens in the blood. However, in the presence of metastatic brain tumors, it is a challenge for drug delivery. Although the blood-tumor barrier is slightly leaky, it still is not permissive enough to allow the accumulation of therapeutic drug concentrations in brain metastases. Herein, we discuss the differences between primary brain tumors and metastatic brain tumors vasculature, effects of therapeutics on the blood-tumor barrier, and characteristics to be manipulated for more effective drug delivery.
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Neurooncol Adv Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Neurooncol Adv Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos