Folic acid oversupplementation during pregnancy disorders lipid metabolism in male offspring via regulating arginase 1-associated NOS3-AMPK&#945; pathway.

Liu, Zhipeng; Zhang, Yuntao; Liu, Zengjiao; Tian, Zhen; Pei, Xinyi; Liu, Liyan; Li, Ying

Folic acid oversupplementation during pregnancy disorders lipid metabolism in male offspring via regulating arginase 1-associated NOS3-AMPKα pathway.

Liu, Zhipeng; Zhang, Yuntao; Liu, Zengjiao; Tian, Zhen; Pei, Xinyi; Liu, Liyan; Li, Ying.

Afiliação

Liu Z; National Key Discipline Laboratory, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, PR China.
Zhang Y; National Key Discipline Laboratory, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, PR China.
Liu Z; National Key Discipline Laboratory, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, PR China.
Tian Z; National Key Discipline Laboratory, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, PR China.
Pei X; National Key Discipline Laboratory, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, PR China.
Liu L; National Key Discipline Laboratory, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, PR China. Electronic address: yanziliu2100@163.com.
Li Y; National Key Discipline Laboratory, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, PR China. Electronic address: liying_helen@163.com.

Clin Nutr ; 41(1): 21-32, 2022 01.

Article em En | MEDLINE | ID: mdl-34864452

Assuntos

Arginase/metabolismo; Suplementos Nutricionais/efeitos adversos; Ácido Fólico/efeitos adversos; Transtornos do Metabolismo dos Lipídeos/induzido quimicamente; Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente; Proteínas Quinases Ativadas por AMP/metabolismo; Animais; Dieta/métodos; Feminino; Ácido Fólico/administração & dosagem; Cromatografia Gasosa-Espectrometria de Massas; Hepatócitos/metabolismo; Metabolismo dos Lipídeos/efeitos dos fármacos; Fígado/metabolismo; Masculino; Metabolômica; Óxido Nítrico Sintase Tipo III/metabolismo; Gravidez; Ratos; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Arginase; Folic acid supplementation; Gestational nutrition; Lipid metabolism; Metabolomics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arginase / Efeitos Tardios da Exposição Pré-Natal / Suplementos Nutricionais / Transtornos do Metabolismo dos Lipídeos / Ácido Fólico Tipo de estudo: Risk_factors_studies Limite: Animals / Pregnancy Idioma: En Revista: Clin Nutr Ano de publicação: 2022 Tipo de documento: Article

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