Synthesis, Biological Evaluation, and Structure-Activity Relationships of 4-Aminopiperidines as Novel Antifungal Agents Targeting Ergosterol Biosynthesis.

Krauß, Jürgen; Müller, Christoph; Klimt, Monika; Valero, Leandro Jorquera; Martínez, José Francisco; Müller, Martin; Bartel, Karin; Binder, Ulrike; Bracher, Franz

Krauß, Jürgen; Müller, Christoph; Klimt, Monika; Valero, Leandro Jorquera; Martínez, José Francisco; Müller, Martin; Bartel, Karin; Binder, Ulrike; Bracher, Franz.

Afiliação

Krauß J; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians University Munich, 81377 Munich, Germany.
Müller C; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians University Munich, 81377 Munich, Germany.
Klimt M; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians University Munich, 81377 Munich, Germany.
Valero LJ; Institute of Hygiene and Medical Microbiology, Department of Hygiene, Microbiology and Public Health, Medical University Innsbruck, Schöpfstr. 41, 6020 Innsbruck, Austria.
Martínez JF; Institute of Hygiene and Medical Microbiology, Department of Hygiene, Microbiology and Public Health, Medical University Innsbruck, Schöpfstr. 41, 6020 Innsbruck, Austria.
Müller M; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians University Munich, 81377 Munich, Germany.
Bartel K; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians University Munich, 81377 Munich, Germany.
Binder U; Institute of Hygiene and Medical Microbiology, Department of Hygiene, Microbiology and Public Health, Medical University Innsbruck, Schöpfstr. 41, 6020 Innsbruck, Austria.
Bracher F; Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians University Munich, 81377 Munich, Germany.

Molecules ; 26(23)2021 Nov 28.

Article em En | MEDLINE | ID: mdl-34885791

Assuntos

Antifúngicos/farmacologia; Ergosterol/metabolismo; Fungos/efeitos dos fármacos; Piperidinas/farmacologia; Antifúngicos/síntese química; Antifúngicos/química; Aspergillus/efeitos dos fármacos; Aspergillus/metabolismo; Vias Biossintéticas/efeitos dos fármacos; Candida/efeitos dos fármacos; Candida/metabolismo; Descoberta de Drogas; Fungos/metabolismo; Humanos; Mucorales/efeitos dos fármacos; Mucorales/metabolismo; Micoses/tratamento farmacológico; Micoses/metabolismo; Piperidinas/síntese química; Piperidinas/química; Relação Estrutura-Atividade

Palavras-chave

4-aminopiperidine; Aspergillus spp.; Candida spp.; Mucorales spp.; antifungals; reductive amination

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Ergosterol / Fungos / Antifúngicos Limite: Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha

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