A double-triggered self-immolative spacer for increased selectivity of molecular release.

Huvelle, Steve; Le Saux, Thomas; Jullien, Ludovic; Schmidt, Frédéric

Huvelle, Steve; Le Saux, Thomas; Jullien, Ludovic; Schmidt, Frédéric.

Afiliação

Huvelle S; i-CleHS, UMR 8060, Chimie ParisTech - PSL, Paris, Île-de-France, France.
Le Saux T; PASTEUR, Département de chimie, École normale supérieure, PSL University, Sorbonne Université, CNRS, 24, rue Lhomond, 75005 Paris, France. Ludovic.Jullien@ens.psl.eu.
Jullien L; PASTEUR, Département de chimie, École normale supérieure, PSL University, Sorbonne Université, CNRS, 24, rue Lhomond, 75005 Paris, France. Ludovic.Jullien@ens.psl.eu.
Schmidt F; Institut Curie, PSL University, CNRS UMR 3666 - INSERM U1143, 26 rue d'Ulm, 75248 PARIS CEDEX 05, FRANCE. Frederic.Schmidt@curie.fr.

Org Biomol Chem ; 20(1): 240-246, 2021 12 22.

Article em En | MEDLINE | ID: mdl-34897358

ABSTRACT

ABSTRACT

A self-immolative spacer based on dissymmetrical N,N'-bis-carbamate aniline is introduced to liberate a substrate from a precursor after dual activation. The proof of principle of its exclusive selectivity for substrate liberation has been conducted on a profluorophore.

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: França

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