Mechanistic Studies of an Automated Lipid Nanoparticle Reveal Critical Pharmaceutical Properties Associated with Enhanced mRNA Functional Delivery In Vitro and In Vivo.

Cui, Lili; Hunter, Morag R; Sonzini, Silvia; Pereira, Sara; Romanelli, Steven M; Liu, Kai; Li, Weimin; Liang, Lihuan; Yang, Bin; Mahmoudi, Najet; Desai, Arpan S

Cui, Lili; Hunter, Morag R; Sonzini, Silvia; Pereira, Sara; Romanelli, Steven M; Liu, Kai; Li, Weimin; Liang, Lihuan; Yang, Bin; Mahmoudi, Najet; Desai, Arpan S.

Afiliação

Cui L; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB21 6GH, UK.
Hunter MR; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB21 6GH, UK.
Sonzini S; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB21 6GH, UK.
Pereira S; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB21 6GH, UK.
Romanelli SM; University of Michigan Medical School, Department of Molecular & Integrative Physiology, Ann Arbor, MI, 48109-5624, USA.
Liu K; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, 43183, Sweden.
Li W; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB21 6GH, UK.
Liang L; Bioscience Renal, Research and Early Development, Cardiovascular, Renal & Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB21 6GH, UK.
Yang B; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB21 6GH, UK.
Mahmoudi N; Rutherford Appleton Laboratory, ISIS Facility, Science and Technology Facilities Council, Didcot, OX11 0QX, UK.
Desai AS; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, CB21 6GH, UK.

Small ; 18(9): e2105832, 2022 03.

Article em En | MEDLINE | ID: mdl-34914866

Assuntos

COVID-19; Nanopartículas; Humanos; Lipossomos; Nanopartículas/química; RNA Mensageiro/química; SARS-CoV-2

Palavras-chave

hydrophobic surfaces; lipid nanoparticles; mRNA loading; macropinocytosis; particle size

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas / COVID-19 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Small Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido

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