Generation of bispecific antibodies using chemical conjugation methods.
Drug Discov Today Technol
; 40: 13-24, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-34916015
ABSTRACT
Bispecific antibodies combine the specificity of two antibodies into one molecule. During the past two decades, advancement in protein engineering enabled the development of more than 100 bispecific formats, three of which are approved by the FDA for clinical use. In parallel to protein engineering methods, advancement in conjugation chemistries have spurred the use of chemical engineering approaches to generate bispecific antibodies. Herein, we review selected chemical strategies employed to generate bispecific antibodies that cannot be made using protein engineering methods.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anticorpos Biespecíficos
Idioma:
En
Revista:
Drug Discov Today Technol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos