Immunoglobulin A Mucosal Immunity and Altered Respiratory Epithelium in Cystic Fibrosis.
Cells
; 10(12)2021 12 20.
Article
em En
| MEDLINE
| ID: mdl-34944110
ABSTRACT
The respiratory epithelium represents the first chemical, immune, and physical barrier against inhaled noxious materials, particularly pathogens in cystic fibrosis. Local mucus thickening, altered mucociliary clearance, and reduced pH due to CFTR protein dysfunction favor bacterial overgrowth and excessive inflammation. We aimed in this review to summarize respiratory mucosal alterations within the epithelium and current knowledge on local immunity linked to immunoglobulin A in patients with cystic fibrosis.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina A
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Imunidade nas Mucosas
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Mucosa Respiratória
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Fibrose Cística
Limite:
Animals
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Humans
Idioma:
En
Revista:
Cells
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Bélgica