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Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication.
Khomenko, Tatyana M; Shtro, Anna A; Galochkina, Anastasia V; Nikolaeva, Yulia V; Petukhova, Galina D; Borisevich, Sophia S; Korchagina, Dina V; Volcho, Konstantin P; Salakhutdinov, Nariman F.
Afiliação
  • Khomenko TM; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia.
  • Shtro AA; Laboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, Russia.
  • Galochkina AV; Laboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, Russia.
  • Nikolaeva YV; Laboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, Russia.
  • Petukhova GD; Laboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, Russia.
  • Borisevich SS; Laboratory of Physical Chemistry, Ufa Chemistry Institute of the Ufa Federal Research Center, 71 Octyabrya pr., 450054 Ufa, Russia.
  • Korchagina DV; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia.
  • Volcho KP; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia.
  • Salakhutdinov NF; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia.
Molecules ; 26(24)2021 Dec 10.
Article em En | MEDLINE | ID: mdl-34946573
ABSTRACT
Respiratory syncytial virus (RSV) is a critical cause of infant mortality. However, there are no vaccines and adequate drugs for its treatment. We showed, for the first time, that O-linked coumarin-monoterpene conjugates are effective RSV inhibitors. The most potent compounds are active against both RSV serotypes, A and B. According to the results of the time-of-addition experiment, the conjugates act at the early stages of virus cycle. Based on molecular modelling data, RSV F protein may be considered as a possible target.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Vírus Sincicial Respiratório Humano / Cumarínicos / Monoterpenos Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Federação Russa
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Vírus Sincicial Respiratório Humano / Cumarínicos / Monoterpenos Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Federação Russa