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Deciphering the pathogenic role of a variant with uncertain significance for short QT and Brugada syndromes using gene-edited human-induced pluripotent stem cell-derived cardiomyocytes and preclinical drug screening.
El-Battrawy, Ibrahim; Lan, Huan; Cyganek, Lukas; Maywald, Lasse; Zhong, Rujia; Zhang, Feng; Xu, Qiang; Lee, Jihyun; Duperrex, Eliane; Hierlemann, Andreas; Saguner, Ardan M; Duru, Firat; Kovacs, Boldizsar; Huang, Mengying; Liao, Zhenxing; Albers, Sebastian; Müller, Jonas; Dinkel, Hendrik; Rose, Lena; Hohn, Alyssa; Yang, Zhen; Qiao, Lin; Li, Yingrui; Lang, Siegfried; Kleinsorge, Mandy; Mügge, Andreas; Aweimer, Assem; Fan, Xuehui; Diecke, Sebastian; Akin, Ibrahim; Li, Guang; Zhou, Xiaobo.
Afiliação
  • El-Battrawy I; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Lan H; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and Göttingen, Mannheim, Germany.
  • Cyganek L; Department of Cardiology and Angiology, Bergmannsheil Bochum, Medical Clinic II, Ruhr University, Bochum, Germany.
  • Maywald L; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.
  • Zhong R; Stem Cell Unit, Clinic for Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany.
  • Zhang F; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and Göttingen, Mannheim, Germany.
  • Xu Q; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Lee J; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and Göttingen, Mannheim, Germany.
  • Duperrex E; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Hierlemann A; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Saguner AM; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Duru F; Department of Biosystems Science and Engineering, Bioengineering Laboratory, Basel, Switzerland.
  • Kovacs B; Department of Biosystems Science and Engineering, Bioengineering Laboratory, Basel, Switzerland.
  • Huang M; Department of Biosystems Science and Engineering, Bioengineering Laboratory, Basel, Switzerland.
  • Liao Z; Department of Cardiology, Electrophysiology Division, University Heart Center Zurich, Zurich, Switzerland.
  • Albers S; Department of Cardiology, Electrophysiology Division, University Heart Center Zurich, Zurich, Switzerland.
  • Müller J; Department of Cardiology, Electrophysiology Division, University Heart Center Zurich, Zurich, Switzerland.
  • Dinkel H; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Rose L; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Hohn A; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Yang Z; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and Göttingen, Mannheim, Germany.
  • Qiao L; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Li Y; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and Göttingen, Mannheim, Germany.
  • Lang S; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Kleinsorge M; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and Göttingen, Mannheim, Germany.
  • Mügge A; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Aweimer A; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Fan X; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Diecke S; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Akin I; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Li G; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
  • Zhou X; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and Göttingen, Mannheim, Germany.
Clin Transl Med ; 11(12): e646, 2021 12.
Article em En | MEDLINE | ID: mdl-34954893
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Miócitos Cardíacos / Síndrome de Brugada Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Clin Transl Med Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Miócitos Cardíacos / Síndrome de Brugada Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Clin Transl Med Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha