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CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia.
Imayoshi, Natsuki; Yoshioka, Makoto; Tanaka, Kuniaki; Yang, Shyh-Ming; Akahane, Koshi; Toda, Yuki; Hosogi, Shigekuni; Inukai, Takeshi; Okada, Seiji; Maloney, David J; Nakahata, Tatsutoshi; Takita, Junko; Kato, Itaru; Ashihara, Eishi.
Afiliação
  • Imayoshi N; Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan; DC1, Japan Society for the Promotion of Science, Tokyo, Japan.
  • Yoshioka M; ConverGene LLC, Cambridge, MD, USA.
  • Tanaka K; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Yang SM; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
  • Akahane K; Department of Pediatrics, School of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Toda Y; Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan.
  • Hosogi S; Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan.
  • Inukai T; Department of Pediatrics, School of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Okada S; Division of Hematopoiesis, Joint Research Center for Human Retrovirus Infection, Kumamoto, Japan.
  • Maloney DJ; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
  • Nakahata T; Drug Discovery Technology Development Office, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.
  • Takita J; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Kato I; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Ashihara E; Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan. Electronic address: ash@mb.kyoto-phu.ac.jp.
Biochem Biophys Res Commun ; 590: 49-54, 2022 01 29.
Article em En | MEDLINE | ID: mdl-34971957
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rearranjo Gênico / Histona-Lisina N-Metiltransferase / Proteína p300 Associada a E1A / Proteína de Leucina Linfoide-Mieloide / Leucemia-Linfoma Linfoblástico de Células Precursoras / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rearranjo Gênico / Histona-Lisina N-Metiltransferase / Proteína p300 Associada a E1A / Proteína de Leucina Linfoide-Mieloide / Leucemia-Linfoma Linfoblástico de Células Precursoras / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão