Lipofuscin Granule Bisretinoid Oxidation in the Human Retinal Pigment Epithelium forms Cytotoxic Carbonyls.

Yakovleva, Marina; Dontsov, Alexander; Trofimova, Natalia; Sakina, Natalia; Kononikhin, Alexey; Aybush, Arseny; Gulin, Alexander; Feldman, Tatiana; Ostrovsky, Mikhail

Yakovleva, Marina; Dontsov, Alexander; Trofimova, Natalia; Sakina, Natalia; Kononikhin, Alexey; Aybush, Arseny; Gulin, Alexander; Feldman, Tatiana; Ostrovsky, Mikhail.

Afiliação

Yakovleva M; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin st. 4, 119334 Moscow, Russia.
Dontsov A; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin st. 4, 119334 Moscow, Russia.
Trofimova N; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin st. 4, 119334 Moscow, Russia.
Sakina N; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin st. 4, 119334 Moscow, Russia.
Kononikhin A; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin st. 4, 119334 Moscow, Russia.
Aybush A; Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, 121205 Moscow, Russia.
Gulin A; N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygin st. 4, bld. 1, 119991 Moscow, Russia.
Feldman T; N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygin st. 4, bld. 1, 119991 Moscow, Russia.
Ostrovsky M; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin st. 4, 119334 Moscow, Russia.

Int J Mol Sci ; 23(1)2021 Dec 25.

Article em En | MEDLINE | ID: mdl-35008647

Assuntos

Lipofuscina/metabolismo; Epitélio Pigmentado da Retina/metabolismo; Idoso; Aldeídos/metabolismo; Citoplasma/metabolismo; Corantes Fluorescentes/metabolismo; Humanos; Degeneração Macular/metabolismo; Pessoa de Meia-Idade; Oxirredução; Retinoides/metabolismo; Espectrometria de Fluorescência/métodos; Espectrometria de Massa de Íon Secundário/métodos

Palavras-chave

age-related macular degeneration; amphiphilicity; bisretinoid fluorophores; bisretinoid oxidation products; cytotoxic carbonyls; hydrophilicity; lipofuscin granules; retinal pigment epithelium

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epitélio Pigmentado da Retina / Lipofuscina Tipo de estudo: Prognostic_studies Limite: Aged / Humans / Middle aged Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Federação Russa

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