Annexin A3: a newly identified player in storeoperated calcium entry.
Acta Neurobiol Exp (Wars)
; 81(4): 307-313, 2021.
Article
em En
| MEDLINE
| ID: mdl-35014980
ABSTRACT
Storeoperated calcium entry (SOCE) is important for refilling endoplasmic reticulum (ER) Ca2+ stores and Ca2+ signaling. Extracellular Ca2+ is conducted by highly Ca2+selective Orai channels that are activated by stromal interaction molecule proteins (STIMs), which are sensitive ER Ca2+ sensors. We found an approximately fivefold increase in annexin A3a (anxa3a) expression levels in stim2b knockout zebrafish. The present study investigated whether annexin A3 protein is involved in SOCE. We used Ca2+ imaging and electrophysiological recordings to determine the effect of annexin A2, A3, and A6 overexpression on SOCE and Orai-dependent Ca2+ currents (ICRAC) in cultured cells. Annexin A3 increased SOCE amplitude and potentiated Ca2+ ICRAC currents. These results suggest that annexin A3 is a positive modulator of SOCE.
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Base de dados:
MEDLINE
Assunto principal:
Canais de Cálcio
/
Cálcio
/
Anexina A3
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Acta Neurobiol Exp (Wars)
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Polônia