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Stride-level analysis of mouse open field behavior using deep-learning-based pose estimation.
Sheppard, Keith; Gardin, Justin; Sabnis, Gautam S; Peer, Asaf; Darrell, Megan; Deats, Sean; Geuther, Brian; Lutz, Cathleen M; Kumar, Vivek.
Afiliação
  • Sheppard K; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
  • Gardin J; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
  • Sabnis GS; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
  • Peer A; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
  • Darrell M; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
  • Deats S; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
  • Geuther B; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
  • Lutz CM; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
  • Kumar V; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA. Electronic address: vivek.kumar@jax.org.
Cell Rep ; 38(2): 110231, 2022 01 11.
Article em En | MEDLINE | ID: mdl-35021077
Gait and posture are often perturbed in many neurological, neuromuscular, and neuropsychiatric conditions. Rodents provide a tractable model for elucidating disease mechanisms and interventions. Here, we develop a neural-network-based assay that adopts the commonly used open field apparatus for mouse gait and posture analysis. We quantitate both with high precision across 62 strains of mice. We characterize four mutants with known gait deficits and demonstrate that multiple autism spectrum disorder (ASD) models show gait and posture deficits, implying this is a general feature of ASD. Mouse gait and posture measures are highly heritable and fall into three distinct classes. We conduct a genome-wide association study to define the genetic architecture of stride-level mouse movement in the open field. We provide a method for gait and posture extraction from the open field and one of the largest laboratory mouse gait and posture data resources for the research community.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Equilíbrio Postural / Marcha Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Equilíbrio Postural / Marcha Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos