Terpyridine copper(II) complexes as potential anticancer agents by inhibiting cell proliferation, blocking the cell cycle and inducing apoptosis in BEL-7402 cells.

Gu, Yun-Qiong; Zhong, Yu-Jun; Hu, Mei-Qi; Li, Huan-Qing; Yang, Kun; Dong, Qi; Liang, Hong; Chen, Zhen-Feng

Gu, Yun-Qiong; Zhong, Yu-Jun; Hu, Mei-Qi; Li, Huan-Qing; Yang, Kun; Dong, Qi; Liang, Hong; Chen, Zhen-Feng.

Afiliação

Gu YQ; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China. hliang@gxnu.edu.cn.
Zhong YJ; School of Environment and Life Science, Nanning Normal University, Nanning, 530001, P. R China.
Hu MQ; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China. hliang@gxnu.edu.cn.
Li HQ; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China. hliang@gxnu.edu.cn.
Yang K; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China. hliang@gxnu.edu.cn.
Dong Q; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China. hliang@gxnu.edu.cn.
Liang H; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China. hliang@gxnu.edu.cn.
Chen ZF; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China. hliang@gxnu.edu.cn.

Dalton Trans ; 51(5): 1968-1978, 2022 Feb 01.

Article em En | MEDLINE | ID: mdl-35023532

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Ciclo Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Piridinas/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Cálcio/metabolismo; Caspase 3/genética; Caspase 3/metabolismo; Caspase 9/genética; Caspase 9/metabolismo; Linhagem Celular Tumoral; Cisplatino/farmacologia; Complexos de Coordenação; Cobre; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Modelos Moleculares; Estrutura Molecular; Proteínas Proto-Oncogênicas c-bcl-2/genética; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Piridinas/síntese química; Piridinas/química; Espécies Reativas de Oxigênio; Proteína X Associada a bcl-2/genética; Proteína X Associada a bcl-2/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Ciclo Celular / Sobrevivência Celular / Apoptose / Proliferação de Células / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Dalton Trans Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article

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