TMEM16A inhibits angiotensin II-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner.

Zheng, Huaqing; Li, Xiaolong; Zeng, Xin; Huang, Chengcui; Ma, Mingming; Lv, Xiaofei; Zhang, Yajuan; Sun, Lu; Wang, Guanlei; Du, Yanhua; Guan, Yongyuan

Zheng, Huaqing; Li, Xiaolong; Zeng, Xin; Huang, Chengcui; Ma, Mingming; Lv, Xiaofei; Zhang, Yajuan; Sun, Lu; Wang, Guanlei; Du, Yanhua; Guan, Yongyuan.

Afiliação

Zheng H; Department of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Li X; Department of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Zeng X; Department of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Huang C; Department of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Ma M; Department of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Lv X; Department of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Zhang Y; Department of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Sun L; Department of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Wang G; Department of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Du Y; Department of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Guan Y; Department of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

Acta Pharm Sin B ; 11(12): 3994-4007, 2021 Dec.

Article em En | MEDLINE | ID: mdl-35024321

Palavras-chave

AngII, angiotensin II; BASMCs, basilar artery smooth muscle cells; CaCC, Ca2+-activated chloride channel; F-actin, filamentous actin; FAK; FAK, focal adhesion kinase; Hypertension; Integrin; MLC20, myosin light chain 20; MLCK, myosin light chain kinase; MLCP, myosin light chain phosphates; MYPT1, myosin phosphatase target subunit 1; RhoA/ROCK; SMTg, smooth muscle-specific TMEM16A transgenic mice; TMEM16A; VSMC migration; VSMCs, vascular smooth muscle cells; Vascular remodeling; WNK1; WNK1, with-no-lysine kinase 1

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Acta Pharm Sin B Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

Texto completo

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XML

PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Acta Pharm Sin B Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China