Inhaled corticosteroids reduce senescence in endothelial progenitor cells from patients with COPD.
Thorax
; 77(6): 616-620, 2022 06.
Article
em En
| MEDLINE
| ID: mdl-35027472
ABSTRACT
Cellular senescence contributes to the pathophysiology of chronic obstructive pulmonary disease (COPD) and cardiovascular disease. Using endothelial colony-forming-cells (ECFC), we have demonstrated accelerated senescence in smokers and patients with COPD compared with non-smokers. Subgroup analysis suggests that ECFC from patients with COPD on inhaled corticosteroids (ICS) (n=14; eight on ICS) exhibited significantly reduced senescence (Senescence-associated-beta galactosidase activity, p21CIP1), markers of DNA damage response (DDR) and IFN-γ-inducible-protein-10 compared with patients with COPD not on ICS. In vitro studies using human-umbilical-vein-endothelial-cells showed a protective effect of ICS on the DDR, senescence and apoptosis caused by oxidative stress, suggesting a protective molecular mechanism of action of corticosteroids on endothelium.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença Pulmonar Obstrutiva Crônica
/
Células Progenitoras Endoteliais
Limite:
Humans
Idioma:
En
Revista:
Thorax
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Reino Unido