Critical changes in hypothalamic gene networks in response to pancreatic cancer as found by single-cell RNA sequencing.

Huisman, Christian; Norgard, Mason A; Levasseur, Peter R; Krasnow, Stephanie M; van der Wijst, Monique G P; Olson, Brennan; Marks, Daniel L

Huisman, Christian; Norgard, Mason A; Levasseur, Peter R; Krasnow, Stephanie M; van der Wijst, Monique G P; Olson, Brennan; Marks, Daniel L.

Afiliação

Huisman C; Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, United States; Knight Cancer Institute, Oregon Health & Science University, Portland, United States. Electronic address: huisman@ohsu.edu.
Norgard MA; Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, United States.
Levasseur PR; Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, United States.
Krasnow SM; Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, United States.
van der Wijst MGP; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Olson B; Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, United States; Medical Scientist Training Program, Oregon Health & Science University, Portland, United States.
Marks DL; Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, United States; Knight Cancer Institute, Oregon Health & Science University, Portland, United States; Brenden-Colson Center for Pancreatic Care, Oregon Health & Science University, Portland, United Sta

Mol Metab ; 58: 101441, 2022 04.

Article em En | MEDLINE | ID: mdl-35031523

Assuntos

Caquexia; Neoplasias Pancreáticas; Animais; Caquexia/metabolismo; Células Endoteliais/metabolismo; Redes Reguladoras de Genes; Hipotálamo/metabolismo; Camundongos; Neoplasias Pancreáticas/complicações; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/metabolismo; Análise de Sequência de RNA; Microambiente Tumoral; Neoplasias Pancreáticas

Palavras-chave

Cachexia models; Endothelial inflammation; Food intake regulation; Neuroinflammation; Pancreatic cancer; scRNA-seq of the central nervous system

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Caquexia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Metab Ano de publicação: 2022 Tipo de documento: Article

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