Palladium-Catalyzed Cascade C-H Functionalization/Asymmetric Allylation Reaction of Aryl α-Diazoamides and Allenes: Lewis Acid Makes a Difference.
Chemistry
; 28(11): e202104218, 2022 Feb 19.
Article
em En
| MEDLINE
| ID: mdl-35043467
ABSTRACT
A Pd-catalyzed cascade C-H functionalization/asymmetric allylation reaction with aryl α-diazoamides and allenes has been developed. The reaction provides an efficient approach to construct chiral 3,3-disubstituted oxindole derivatives in high levels of yield and enantioselectivity (up to 93 % ee). Notably, the chromium complex works as Lewis acid to facilitate the formation of palladium carbene and to enhance acidity of carboxylic acid, allowing for higher stereochemical control and efficiency.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Paládio
/
Alcadienos
Idioma:
En
Revista:
Chemistry
Assunto da revista:
QUIMICA
Ano de publicação:
2022
Tipo de documento:
Article