Measuring infectious SARS-CoV-2 in clinical samples reveals a higher viral titer:RNA ratio for Delta and Epsilon vs. Alpha variants.

Despres, Hannah W; Mills, Margaret G; Shirley, David J; Schmidt, Madaline M; Huang, Meei-Li; Roychoudhury, Pavitra; Jerome, Keith R; Greninger, Alexander L; Bruce, Emily A

Despres, Hannah W; Mills, Margaret G; Shirley, David J; Schmidt, Madaline M; Huang, Meei-Li; Roychoudhury, Pavitra; Jerome, Keith R; Greninger, Alexander L; Bruce, Emily A.

Afiliação

Despres HW; Department of Microbiology and Molecular Genetics, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT 05405.
Mills MG; Virology Division, Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98105.
Shirley DJ; Data Science Department, Faraday, Inc., Burlington, VT 05405.
Schmidt MM; Department of Microbiology and Molecular Genetics, Robert Larner, M.D. College of Medicine, University of Vermont, Burlington, VT 05405.
Huang ML; Virology Division, Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98105.
Roychoudhury P; Virology Division, Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98105.
Jerome KR; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.
Greninger AL; Virology Division, Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98105.
Bruce EA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.

Proc Natl Acad Sci U S A ; 119(5)2022 02 01.

Article em En | MEDLINE | ID: mdl-35058348

Assuntos

COVID-19/epidemiologia; Regulação Viral da Expressão Gênica; Genoma Viral; RNA Viral/genética; SARS-CoV-2/genética; SARS-CoV-2/patogenicidade; Animais; COVID-19/patologia; COVID-19/transmissão; COVID-19/virologia; Linhagem Celular Tumoral; Chlorocebus aethiops; Proteínas do Envelope de Coronavírus/genética; Proteínas do Envelope de Coronavírus/metabolismo; Hepatócitos/metabolismo; Hepatócitos/virologia; Humanos; RNA Viral/metabolismo; SARS-CoV-2/classificação; SARS-CoV-2/metabolismo; Células Vero; Carga Viral; Virulência

Palavras-chave

Delta; SARS-CoV-2; infectivity; variant; viral load

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Viral / Regulação Viral da Expressão Gênica / Genoma Viral / SARS-CoV-2 / COVID-19 Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article

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