Transcriptional effects of fingolimod treatment on peripheral T cells in relapsing remitting multiple sclerosis patients.
Pharmacogenomics
; 23(3): 161-171, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-35068175
ABSTRACT
Aim:
To investigate the transcriptional changes induced by Fingolimod (FTY) in T cells of relapsing remitting multiple sclerosis patients. Patients &methods:
Transcriptomic changes after 6 months of FTY therapy were evaluated on T cells from 24 relapsing remitting multiple sclerosis patients through RNA-sequencing, followed by technical validation and pathway analysis.Results:
Among differentially expressed genes, CX3CR1 and CCR7 resulted strongly up- and downregulated, respectively. Two relevant genes were validated with quantitative PCR and we largely confirmed findings from two previous microarray-based studies with similar design. Pathway analysis pointed to an involvement of processes related to immune function and cell migration.Conclusion:
Our data support the evidence that FTY induces major transcriptional changes in genes involved in immune response and cell trafficking in T lymphocytes.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Esclerose Múltipla Recidivante-Remitente
/
Transcriptoma
/
Cloridrato de Fingolimode
/
Imunossupressores
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Pharmacogenomics
Assunto da revista:
FARMACOLOGIA
/
GENETICA MEDICA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Itália