The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis.

Zhu, Youming; Jin, Lei; Shi, Ronghua; Li, Jinming; Wang, Yan; Zhang, Li; Liang, Chao-Zhao; Narayana, Vinod K; De Souza, David P; Thorne, Rick F; Zhang, Li Rong; Zhang, Xu Dong; Wu, Mian

Zhu, Youming; Jin, Lei; Shi, Ronghua; Li, Jinming; Wang, Yan; Zhang, Li; Liang, Chao-Zhao; Narayana, Vinod K; De Souza, David P; Thorne, Rick F; Zhang, Li Rong; Zhang, Xu Dong; Wu, Mian.

Afiliação

Zhu Y; Translational Research Institute, Henan Provincial People's Hospital, Academy of Medical Science, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou 450003, China; Department of Dental Implant Center, Stomatologic Hospital and College, Anhui Medical U
Jin L; Translational Research Institute, Henan Provincial People's Hospital, Academy of Medical Science, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou 450003, China; School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW 2308,
Shi R; The Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Cell and Molecular Biology, School of Life Sciences, University of Science and Technology of China, Hefei 230026, China.
Li J; Translational Research Institute, Henan Provincial People's Hospital, Academy of Medical Science, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou 450003, China.
Wang Y; Translational Research Institute, Henan Provincial People's Hospital, Academy of Medical Science, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou 450003, China.
Zhang L; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230031, China.
Liang CZ; Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230031, China.
Narayana VK; Bio21 Institute and Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC 3010, Australia; Metabolomics Australia, University of Melbourne, Parkville, VIC 3010, Australia.
De Souza DP; Bio21 Institute and Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC 3010, Australia; Metabolomics Australia, University of Melbourne, Parkville, VIC 3010, Australia.
Thorne RF; Translational Research Institute, Henan Provincial People's Hospital, Academy of Medical Science, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou 450003, China; School of Environmental and Life Sciences, The University of Newcastle, Newcastle, NSW
Zhang LR; Translational Research Institute, Henan Provincial People's Hospital, Academy of Medical Science, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou 450003, China. Electronic address: lrzhang@zzu.edu.cn.
Zhang XD; Translational Research Institute, Henan Provincial People's Hospital, Academy of Medical Science, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou 450003, China; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, NSW
Wu M; Translational Research Institute, Henan Provincial People's Hospital, Academy of Medical Science, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou 450003, China; The Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Dis

Mol Cell ; 82(3): 542-554.e6, 2022 02 03.

Article em En | MEDLINE | ID: mdl-35081364

Assuntos

Biomarcadores Tumorais/metabolismo; Proteínas de Transporte/metabolismo; Proteínas de Ligação a DNA/metabolismo; Glicólise; Proteínas de Membrana/metabolismo; Neoplasias/enzimologia; Fosfoglicerato Quinase/metabolismo; Fosfoglicerato Mutase/metabolismo; Fosfopiruvato Hidratase/metabolismo; RNA Longo não Codificante/metabolismo; Hormônios Tireóideos/metabolismo; Proteínas Supressoras de Tumor/metabolismo; Trifosfato de Adenosina/metabolismo; Animais; Biomarcadores Tumorais/genética; Proteínas de Transporte/genética; Proliferação de Células; Proteínas de Ligação a DNA/genética; Feminino; Regulação Enzimológica da Expressão Gênica; Regulação Neoplásica da Expressão Gênica; Células HEK293; Células HeLa; Células Hep G2; Humanos; L-Lactato Desidrogenase/genética; L-Lactato Desidrogenase/metabolismo; Proteínas de Membrana/genética; Camundongos Nus; Complexos Multienzimáticos; Neoplasias/genética; Neoplasias/patologia; Fosfoglicerato Quinase/genética; Fosfoglicerato Mutase/genética; Fosfopiruvato Hidratase/genética; Proteínas Proto-Oncogênicas c-myc/genética; Proteínas Proto-Oncogênicas c-myc/metabolismo; RNA Longo não Codificante/genética; Serina/deficiência; Hormônios Tireóideos/genética; Carga Tumoral; Proteínas Supressoras de Tumor/genética; Proteínas de Ligação a Hormônio da Tireoide

Palavras-chave

c-Myc; glycoLINC; glycolytic complex; metabolon; serine starvation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfoglicerato Quinase / Fosfopiruvato Hidratase / Hormônios Tireóideos / Proteínas de Transporte / Biomarcadores Tumorais / Fosfoglicerato Mutase / Proteínas Supressoras de Tumor / Proteínas de Ligação a DNA / RNA Longo não Codificante / Glicólise Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2022 Tipo de documento: Article

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