Efficacy of D-cycloserine augmented brief intensive cognitive-behavioural therapy for paediatric obsessive-compulsive disorder: A randomised clinical trial.
Depress Anxiety
; 39(6): 461-473, 2022 06.
Article
em En
| MEDLINE
| ID: mdl-35084071
ABSTRACT
OBJECTIVE:
To examine the efficacy of weight-adjusted D-cycloserine (DCS) (35 or 70 mg) relative to placebo augmentation of intensive exposure therapy for youth with obsessive-compulsive disorder (OCD) in a double-blind, randomised controlled trial, and examine whether antidepressant medication or patient age moderated outcomes.METHODS:
Youth (n = 100, 7-17 years) with OCD were randomised in a 11 ratio to either DCS + exposure (n = 49) or placebo + exposure (n = 51). Assessments occurred posttreatment, 1 month later, and at 3 and 6 months. Pills were ingested immediately before sessions.RESULTS:
Significant improvements on all outcomes were observed at posttreatment, and to 6-month follow-up. Treatment arms did not differ across time, with no significant time-by-medication interactions on symptom severity (T1 to T2 estimate 9.3, 95% confidence interval [CI] -11.2 to -7.4, and estimate -10.7, 95% CI -12.6 to -8.7), diagnostic severity (T1 to T2 estimate -2.0, 95% CI -2.4 to -1.5 and estimate -2.5, 95% CI -3.0 to -2.0) or global functioning (T1 to T2 estimate 13.8, 95% CI 10.6 to 17.0, and estimate 16.6, 95% CI 13.2 to 19.9). Neither antidepressants at baseline nor age moderated primary outcomes. There were significantly fewer responders/remitters at 1- and 6-month follow-up among youth in the DCS condition stabilised on SSRIs, relative to youth not taking SSRIs.CONCLUSIONS:
DCS augmented intensive exposure therapy did not result in overall additional benefits relative to placebo. Intensive exposure proved effective in reducing symptoms for the overall sample.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terapia Cognitivo-Comportamental
/
Transtorno Obsessivo-Compulsivo
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Child
/
Humans
Idioma:
En
Revista:
Depress Anxiety
Assunto da revista:
PSIQUIATRIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Austrália