Elevation of Extracellular Glutamate by Blockade of Astrocyte Glutamate Transporters Inhibits Cocaine Reinforcement in Rats via a NMDA-GluN2B Receptor Mechanism.

Yang, Hong-Ju; Hempel, Briana J; Bi, Guo-Hua; He, Yi; Zhang, Hai-Ying; Gardner, Eliot L; Xi, Zheng-Xiong

Yang, Hong-Ju; Hempel, Briana J; Bi, Guo-Hua; He, Yi; Zhang, Hai-Ying; Gardner, Eliot L; Xi, Zheng-Xiong.

Afiliação

Yang HJ; Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224.
Hempel BJ; Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224.
Bi GH; Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224.
He Y; Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224.
Zhang HY; Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224.
Gardner EL; Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224.
Xi ZX; Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224 zxi@mail.nih.gov.

J Neurosci ; 42(11): 2327-2343, 2022 03 16.

Article em En | MEDLINE | ID: mdl-35091501

Assuntos

Transtornos Relacionados ao Uso de Cocaína; Cocaína; Sistema X-AG de Transporte de Aminoácidos/metabolismo; Animais; Astrócitos/metabolismo; Cocaína/farmacologia; Transtornos Relacionados ao Uso de Cocaína/metabolismo; Feminino; Ácido Glutâmico/metabolismo; Masculino; N-Metilaspartato/farmacologia; Núcleo Accumbens; Ratos; Receptores de N-Metil-D-Aspartato; Autoadministração

Palavras-chave

TFB-TBOA; astrocyte; cocaine; glutamate; glutamate transporter; reward

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cocaína / Transtornos Relacionados ao Uso de Cocaína Limite: Animals Idioma: En Revista: J Neurosci Ano de publicação: 2022 Tipo de documento: Article

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