Synapses, Microglia, and Lipids in Alzheimer's Disease.
Front Neurosci
; 15: 778822, 2021.
Article
em En
| MEDLINE
| ID: mdl-35095394
ABSTRACT
Alzheimer's disease (AD) is characterised by synaptic dysfunction accompanied by the microscopically visible accumulation of pathological protein deposits and cellular dystrophy involving both neurons and glia. Late-stage AD shows pronounced loss of synapses and neurons across several differentially affected brain regions. Recent studies of advanced AD using post-mortem brain samples have demonstrated the direct involvement of microglia in synaptic changes. Variants of the Apolipoprotein E and Triggering Receptors Expressed on Myeloid Cells gene represent important determinants of microglial activity but also of lipid metabolism in cells of the central nervous system. Here we review evidence that may help to explain how abnormal lipid metabolism, microglial activation, and synaptic pathophysiology are inter-related in AD.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Front Neurosci
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Austrália