SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes.

Xie, Yuchen; Sahin, Merve; Sinha, Sonali; Wang, Yufeng; Nargund, Amrita M; Lyu, Yang; Han, Song; Dong, Yiyu; Hsieh, James J; Leslie, Christina S; Cheng, Emily H

Xie, Yuchen; Sahin, Merve; Sinha, Sonali; Wang, Yufeng; Nargund, Amrita M; Lyu, Yang; Han, Song; Dong, Yiyu; Hsieh, James J; Leslie, Christina S; Cheng, Emily H.

Afiliação

Xie Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sahin M; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA.
Sinha S; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Wang Y; Tri-Institutional Training Program in Computational Biology and Medicine, New York, NY, USA.
Nargund AM; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lyu Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Han S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Dong Y; Molecular Oncology, Department of Medicine, Washington University, St. Louis, MO, USA.
Hsieh JJ; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Leslie CS; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cheng EH; Molecular Oncology, Department of Medicine, Washington University, St. Louis, MO, USA. jhsieh@wustl.edu.

Nat Cancer ; 3(2): 188-202, 2022 02.

Article em En | MEDLINE | ID: mdl-35115713

Assuntos

Carcinoma de Células Renais; Histona-Lisina N-Metiltransferase/metabolismo; Neoplasias Renais; Animais; Carcinogênese/genética; Carcinoma de Células Renais/genética; Proteínas de Ciclo Celular/genética; Epigênese Genética; Feminino; Chaperonas de Histonas/genética; Histona-Lisina N-Metiltransferase/genética; Histonas/genética; Humanos; Neoplasias Renais/genética; Masculino; Camundongos; Chaperonas Moleculares/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Histona-Lisina N-Metiltransferase / Neoplasias Renais Tipo de estudo: Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Nat Cancer Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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