Exposure Levels and Contributing Factors of Various Arsenic Species and Their Health Effects on Korean Adults.
Arch Environ Contam Toxicol
; 82(3): 391-402, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-35132447
ABSTRACT
Arsenic is a human carcinogen. Data on urinary arsenic species analyses of Koreans are limited. This study evaluated the arsenic exposure level, contributing factors, and health effects in Korean adults. Dietary intake information and urine samples were obtained from 2044 participants. Arsenic exposure was assessed based on urinary concentrations of arsenic species, such as inorganic arsenic, As(III) and As(V), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and arsenobetaine (AsB), using high-performance liquid chromatography with inductively coupled plasma mass spectrometry, followed by determination of biomarkers, malondialdehyde and c-peptide. The geometric mean concentrations were 30.9 µg/L for the sum of inorganic arsenic and their metabolites, and 84.7 µg/L for the total sum of arsenic measured. Urinary concentrations of arsenic species were influenced by age, inhabitant area (inland or coastal), and seafood intake, which was positively correlated with inorganic arsenic, DMA, and AsB. Rice intake was positively correlated with inorganic arsenic and its metabolites but not with AsB. Additionally, malondialdehyde and c-peptide levels were significantly associated with urinary concentrations of various arsenic species. Seafood and rice are major sources of organic/inorganic arsenic exposure in Korean adults; however, it is necessary to evaluate whether their overconsumption could have a potentially detrimental effect on human health.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Arsênio
/
Oryza
Limite:
Adult
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Arch Environ Contam Toxicol
Ano de publicação:
2022
Tipo de documento:
Article