Gut bacterial metabolite Urolithin A inhibits myocardial fibrosis through activation of Nrf2 pathway in vitro and in vivo.

Chen, Pengfei; Pei, Junyu; Wang, Xiaopu; Tai, Shi; Tang, Liang; Hu, Xinqun

Chen, Pengfei; Pei, Junyu; Wang, Xiaopu; Tai, Shi; Tang, Liang; Hu, Xinqun.

Afiliação

Chen P; Department of Cardiology, The Second Xiangya Hospital of Central South University, No.139, Middle Ren-min Road, Changsha, 410011, Hunan Province, People's Republic of China.
Pei J; Department of Cardiology, The Second Xiangya Hospital of Central South University, No.139, Middle Ren-min Road, Changsha, 410011, Hunan Province, People's Republic of China.
Wang X; Department of Cardiology, The Second Xiangya Hospital of Central South University, No.139, Middle Ren-min Road, Changsha, 410011, Hunan Province, People's Republic of China.
Tai S; Department of Cardiology, The Second Xiangya Hospital of Central South University, No.139, Middle Ren-min Road, Changsha, 410011, Hunan Province, People's Republic of China.
Tang L; Department of Cardiology, The Second Xiangya Hospital of Central South University, No.139, Middle Ren-min Road, Changsha, 410011, Hunan Province, People's Republic of China.
Hu X; Department of Cardiology, The Second Xiangya Hospital of Central South University, No.139, Middle Ren-min Road, Changsha, 410011, Hunan Province, People's Republic of China. hxqsci@csu.edu.cn.

Mol Med ; 28(1): 19, 2022 02 08.

Article em En | MEDLINE | ID: mdl-35135471

Assuntos

Cumarínicos/farmacologia; Microbioma Gastrointestinal; Miocárdio/metabolismo; Miocárdio/patologia; Fator 2 Relacionado a NF-E2/metabolismo; Transdução de Sinais/efeitos dos fármacos; Animais; Biomarcadores; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Cumarínicos/metabolismo; Fibrose; Infarto do Miocárdio/etiologia; Infarto do Miocárdio/metabolismo; Infarto do Miocárdio/patologia; Miofibroblastos/efeitos dos fármacos; Miofibroblastos/metabolismo; Ratos

Palavras-chave

Myocardial fibrosis; Myofibroblast transformation; Nrf2; Urolithin A

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Cumarínicos / Fator 2 Relacionado a NF-E2 / Microbioma Gastrointestinal / Miocárdio Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2022 Tipo de documento: Article

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