G&#945;<sub>12</sub> overexpression in hepatocytes by ER stress exacerbates acute liver injury via ROCK1-mediated miR-15a and ALOX12 dysregulation.

Tak, Jihoon; Kim, Yun Seok; Kim, Tae Hyun; Park, Gil-Chun; Hwang, Shin; Kim, Sang Geon

Gα₁₂ overexpression in hepatocytes by ER stress exacerbates acute liver injury via ROCK1-mediated miR-15a and ALOX12 dysregulation.

Tak, Jihoon; Kim, Yun Seok; Kim, Tae Hyun; Park, Gil-Chun; Hwang, Shin; Kim, Sang Geon.

Afiliação

Tak J; College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Kim YS; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Kim TH; College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Park GC; Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
Hwang S; Drug Information Research Institute, College of Pharmacy, Sookmyung Women's University, Seoul 04310, Republic of Korea.
Kim SG; Department of Surgery, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Republic of Korea.

Theranostics ; 12(4): 1570-1588, 2022.

Article em En | MEDLINE | ID: mdl-35198058

Assuntos

Endorribonucleases; MicroRNAs; Acetaminofen/toxicidade; Animais; Araquidonato 12-Lipoxigenase/metabolismo; Estresse do Retículo Endoplasmático/genética; Endorribonucleases/metabolismo; Hepatócitos/metabolismo; Humanos; Fígado/metabolismo; Camundongos; MicroRNAs/genética; MicroRNAs/metabolismo; Proteínas Serina-Treonina Quinases; Quinases Associadas a rho/genética; Quinases Associadas a rho/metabolismo

Palavras-chave

ALOX12; GPX4; Gα12; acetaminophen-induced liver injury; miR-15a

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Endorribonucleases Limite: Animals / Humans Idioma: En Revista: Theranostics Ano de publicação: 2022 Tipo de documento: Article

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