Preclinical Identification of Sulfasalazine's Therapeutic Potential for Suppressing Colorectal Cancer Stemness and Metastasis through Targeting KRAS/MMP7/CD44 Signaling.

Leung, Wai-Hung; Shih, Jing-Wen; Chen, Jian-Syun; Mokgautsi, Ntlotlang; Wei, Po-Li; Huang, Yan-Jiun

Leung, Wai-Hung; Shih, Jing-Wen; Chen, Jian-Syun; Mokgautsi, Ntlotlang; Wei, Po-Li; Huang, Yan-Jiun.

Afiliação

Leung WH; Division of Colon and Rectal Surgery, Department of Surgery, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei 10449, Taiwan.
Shih JW; Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan.
Chen JS; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Mokgautsi N; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Wei PL; Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Huang YJ; Division of Colon and Rectal Surgery, Department of Surgery, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei 10449, Taiwan.

Biomedicines ; 10(2)2022 Feb 04.

Article em En | MEDLINE | ID: mdl-35203586

Palavras-chave

cancer stem cell (CSC); chemotherapy enhancement; colorectal cancer (CRC); metastasis; sulfasalazine

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Biomedicines Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Taiwan

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