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A Review of Circulating Tumor DNA in the Diagnosis and Monitoring of Esophageal Cancer.
Min, Jiang; Zhou, Huilin; Jiang, Su; Yu, Hong.
Afiliação
  • Min J; Department of Pathology, Taizhou People's Hospital, Affiliated to Nanjing University of Traditional Chinese Medicine, Taizhou, Jiangsu, China (mainland).
  • Zhou H; Department of Pathology, Taizhou People's Hospital, Affiliated to Nanjing University of Traditional Chinese Medicine, Taizhou, Jiangsu, China (mainland).
  • Jiang S; Department of Rehabilitation, Taizhou People's Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Taizhou, Jiangsu, China (mainland).
  • Yu H; Department of Pathology, Taizhou People's Hospital, Affiliated to Nanjing University of Traditional Chinese Medicine, Taizhou, Jiangsu, China (mainland).
Med Sci Monit ; 28: e934106, 2022 Feb 25.
Article em En | MEDLINE | ID: mdl-35210388
ABSTRACT
Circulating tumor DNA (ctDNA) is a type of cell-free DNA released by tumor cells after necrosis and apoptosis, and it can be actively secreted by tumor cells. Since ctDNA is derived from various tumor sites, it can provide far more comprehensive genomic and epigenomic information than a single-site biopsy. Therefore, ctDNA can overcome tumor heterogeneity, which is the major limitation of a traditional tissue biopsy approach. Noninvasive ctDNA assays allow continuous real-time monitoring of the molecular status of cancers. Recently, ctDNA assays have been widely used in clinical practice, including cancer diagnosis, evaluation of therapeutic efficacy and prognosis, and monitoring of relapse and metastasis. Although ctDNA shows a high diagnostic performance in advanced esophageal cancer, it is far from satisfactory for early diagnosis of esophageal cancer. Monitoring the dynamic changes of ctDNA is beneficial for the evaluation of therapeutic efficacy and prediction of early recurrence in esophageal cancer. It is necessary to establish standards for individualized ctDNA detection in the evaluation of treatment response and surveillance of esophageal cancer and to develop clinical practice guideline for the systemic treatment of patients with "ctDNA recurrence." This review aims to provide an update on the role of ctDNA in the diagnosis and monitoring of esophageal cancer.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Ácidos Nucleicos Livres / DNA Tumoral Circulante / Mutação Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Med Sci Monit Assunto da revista: MEDICINA Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Ácidos Nucleicos Livres / DNA Tumoral Circulante / Mutação Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Revista: Med Sci Monit Assunto da revista: MEDICINA Ano de publicação: 2022 Tipo de documento: Article