Acromegaly: Medical and Surgical Considerations.
Otolaryngol Clin North Am
; 55(2): 331-341, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-35256175
ABSTRACT
Acromegaly results from excessive secretion of insulinlike growth factor-1 and growth hormone, which most commonly occurs because of pituitary somatotrophinoma. Diagnostic features of acromegaly include elevated insulinlike growth factor-1 and growth hormone; lesion on brain MRI; and clinically dysmorphic features, such as soft tissue swelling, jaw prognathism, and acral overgrowth. Transsphenoidal resection is the primary therapy for individuals with acromegaly, even in the cases where gross total resection is not possible because of parasellar extension and cavernous sinus involvement. For recurrent or persistent disease after resection, systemic medications and stereotactic radiosurgery are used.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Hipofisárias
/
Acromegalia
/
Adenoma
/
Radiocirurgia
/
Hormônio do Crescimento Humano
/
Adenoma Hipofisário Secretor de Hormônio do Crescimento
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Otolaryngol Clin North Am
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos