Platinum-Based Chemotherapy 'Rechallenge' in Advanced Non-ovarian Solid Malignancies.
Clin Oncol (R Coll Radiol)
; 34(8): e329-e344, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-35282934
ABSTRACT
Platinum-based chemotherapy forms the backbone of treatment for many solid cancers. However, resistance inevitably develops in those with advanced disease. Platinum rechallenge is a well-established concept in the management of ovarian cancer, small cell lung cancer and germ cell tumours. In other solid malignancies there is a lack of quality evidence to support platinum rechallenge, yet it is a widely adopted strategy. Often, patients are within the last year of life, making questions of efficacy, treatment-related toxicity and quality of life critical factors for treatment recommendations. In this overview we appraise the available evidence for platinum rechallenge and strategies being developed to attempt resensitisation of tumours to platinum-based chemotherapy.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Neoplasias Pulmonares
Tipo de estudo:
Guideline
Limite:
Female
/
Humans
Idioma:
En
Revista:
Clin Oncol (R Coll Radiol)
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2022
Tipo de documento:
Article