Disulfiram prevents collagen crosslinking and inhibits renal fibrosis by inhibiting lysyl oxidase enzymes.

Saifi, Mohd Aslam; Shaikh, Arbaz Sujat; Kaki, Venkata Rao; Godugu, Chandraiah

Saifi, Mohd Aslam; Shaikh, Arbaz Sujat; Kaki, Venkata Rao; Godugu, Chandraiah.

Afiliação

Saifi MA; Department of Biological Sciences (Regulatory Toxicology), National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.
Shaikh AS; Department of Chemical Sciences, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India.
Kaki VR; Department of Chemical Sciences, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India.
Godugu C; Department of Biological Sciences (Regulatory Toxicology), National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.

J Cell Physiol ; 237(5): 2516-2527, 2022 05.

Article em En | MEDLINE | ID: mdl-35285015

Assuntos

Nefropatias; Proteína-Lisina 6-Oxidase; Aminopropionitrilo/farmacologia; Animais; Colágeno/metabolismo; Cobre; Dissulfiram/farmacologia; Fibrose; Humanos; Proteína-Lisina 6-Oxidase/metabolismo

Palavras-chave

chronic kidney disease; disulfiram; epithelial to mesenchymal transition; lysyl oxidase; renal fibrosis

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nefropatias / Proteína-Lisina 6-Oxidase Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Cell Physiol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google