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Alterations of gut microbiota-derived metabolites in gestational diabetes mellitus and clinical significance.
Gao, Yajie; Chen, Haimin; Li, Jialin; Ren, Shuaijun; Yang, Zhenglun; Zhou, Yuping; Xuan, Rongrong.
Afiliação
  • Gao Y; Department of Obstetrics and Gynecology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, China.
  • Chen H; Key Laboratory of Applied Marine Biotechnology of Ministry of Education, Ningbo University, Ningbo, China.
  • Li J; School of Medicine, Ningbo University, Ningbo, China.
  • Ren S; School of Medicine, Ningbo University, Ningbo, China.
  • Yang Z; School of Medicine, Ningbo University, Ningbo, China.
  • Zhou Y; Department of Gastroenterology, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, China.
  • Xuan R; Institute of Digestive Disease of Ningbo University, Ningbo, China.
J Clin Lab Anal ; 36(4): e24333, 2022 Apr.
Article em En | MEDLINE | ID: mdl-35285096
ABSTRACT

BACKGROUND:

The change in the characteristics of the gut microbiota is linked to gestational diabetes mellitus (GDM). However, whether and how the gut microbiota-derived metabolites change in GDM is uncertain. Here, we aimed to determine associations between the gut microbiota-derived metabolites and GDM.

METHODS:

Using targeted metabolomics approaches, 7 types of short-chain fatty acids (SCFAs), 38 types of bile acids (BAs), and 5 types of trimethylamine N-oxide (TMAO), and its derivatives of serum samples were obtained from pregnant women with GDM (n = 24), and healthy pregnant controls (HC, n = 28) were detected to identify the metabolic signature of GDM to investigate the potential biomarkers. Moreover, we assessed the associations between gut microbiota-derived metabolites and clinical parameters.

RESULTS:

In our study, the gut microbiota-derived metabolites signatures were significantly different between GDM and HC. Quantitative results showed the levels of isobutyric acid, isovaleric acid, valeric acid, caproic acid, GUDCA, THDCA + TUDCA, and LCA-3S were significantly higher in GDM, but the level of TMAO and its derivatives did not change significantly. Some altered gut microbiota-derived metabolites were significantly correlated with glucose and lipid levels. Receiver-operating characteristic (ROC) analysis of generalized linear models showed that gut microbiota-derived metabolites may be potential biomarkers of GDM.

CONCLUSION:

This study highlights gut microbiota-derived metabolites alterations in GDM and correlation of the clinical indicators, which provides a new direction for future studies aiming to novel serum biomarker for early detection or target of drug therapy of GDM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Gestacional / Microbioma Gastrointestinal Tipo de estudo: Prognostic_studies / Screening_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: J Clin Lab Anal Assunto da revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Gestacional / Microbioma Gastrointestinal Tipo de estudo: Prognostic_studies / Screening_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: J Clin Lab Anal Assunto da revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China